Phenacetin was widely used until the third quarter of the twentieth century, often in the form of an "A.P.C." or aspirin- phenacetin-caffeine compound analgesic, as a remedy for fever and pain. However the U.S. Food and Drug Administration ordered the wtihdrawal of drugs containing phenacetin in November 1983, owing to its carcinogenic and kidney-damaging properties (Federal Register of October 5, 1983 (48 FR 45466))> As a result some branded, previously phenacetin-based preparations continued to be sold, but with the phenacetin replaced by safer alternatives.
A popular brand of phenacetin was Roche's Saridon, which was reformulated in 1983 to contain propyphenazone, paracetamol and caffeine. Coricidin was also reformulated without phenacetin. Paracetamol is a metabolite of phenacetin with similar analgesic and antipyretic effects, but the new formulaiton has not been found to have phenacetin carcinogenicity.
Phenacitin is now being used as a cutting agent to adulterate cocaine in the the UK, owing to the similar physical features of the. two drugs
this is scary, kung ginagamit sya for cocaine, bakit sya nasa gamot?
ReplyDeletelukoluko pala tong Saridon na to e... gusto atang maging adik lahat ng bumibili ng gamot nila. Alam ko marami nyan dito sa VISMIN
ReplyDeletehttp://www.noypf.com/adobofy/tag/propyphenazone
ReplyDelete